Pathogenesis of COVID-19 and multi-system inflammatory syndrome in children

World health organization declared COVID-19 caused by SARS CoV-2 virus as a pandemic in early 2020. The target cells facilitating viral entry are ACE-2 receptor bearing like bronchial epithelial and pneumocytes. Children pose less risk compared to adults acquiring this disease mortality them is low due protective pathogenesis. with also at of developing unique immunological phenomena, known multi-system inflammatory syndrome children. MIS-C considered be hyperimmune state resulting from cytokine storm circulating immune complexes. This mini-review reflects the most recent understanding pathogenesis children special emphasis on MIS-C.